A STUDY OF THE INFLUENCE OF RELATIVE ACIDITY, NUMBER OF COMPONENTS AND NOISE LEVEL ON THE MULTIVARIATE pH-METRIC DETERMINATION OF WEAK ACIDS USING SIMULATED DATA
Mojtaba Shamsipur,a,* Bahram Hemmateenejad,b and Morteza Akhondc
a Department of Chemistry,
b Medicinal & Natural Products Chemistry
c Department of Chemistry,
A systematic study has been conducted on the effect different factors including relative acidity, number of components and added noise on the simultaneous determination of weak acids by multivariate pH-metric titration. For this purpose, partial least squares (PLS) regression was applied on the simulated pH-metric titration data. Large numbers of acid mixture systems composed of different number of acids with varying acidity strengths were examined. The effect of added noise on the prediction ability of the PLS regression was also studied.
Key words: pH-metry, simultaneous determination, weak acids, relative acidity, components, noise, PLS