SYNTHESIS AND STUDIES OF ANTIMICROBIAL ACTIVITY OF LANCEOLATIN B

 Sayed Alam
Department of Chemistry,  Rajshahi University of Engineering & Technology, Rajshahi-6204,  Bangladesh .
Tel.: +88-0721-750349; Fax: +88-0721-750105; e-mail: alam_sms@yahoo.com

  Abstract

Phytochemical studies of Pongamia pinnata showed an abundance of [2¢¢, 3¢¢: 7, 8]furanoflavone (lanceolatin B). Now, it has been synthesized from b-resacetophenone via chalcone precursor followed by the treatment of DMSO/I₂, diphenyl sulphide and DDQ, respectively. The antibacterial activity of [2¢¢, 3¢¢: 7, 8]furanoflavone and its corresponding chalcone were tested by the disc diffusion method for antibacterial effects against Shigella dysenteriae, Salmonella typhi, Streptococcus-b-haemolyticus and Staphylococcus aureus.

Key words: Pongamia pinnata, lanceolatin B, antibacterial activity