Zirconyl(IV) Chloride - Catalysed Reaction of Indoles: An Expeditious Synthesis of Bis(indolyl)Methanes

Rahul R. Nagawade a,b and Devanand B. Shinde b*

a Division of Medicinal Chemistry New Drug Discovery ,Wockhardt Research Centre,
Aurangabad - 431210 (M.S.), India
b Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University,
Aurangabad - 431004 (M.S.), India

Zirconyl(IV) chloride is found to be an efficient catalyst for the electrophilic substitution reaction of indole with aldehydes / ketones to afford the corresponding bis(indolyl)methanes in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles and simple experimental and work-up procedures.

Key words: Zirconyl(IV) chloride, aldehydes, ketones, bis(indolyl)methanes, indole