Synthesis and Structural Characterization of Pyrazino[1,3]diazepines, as a New Ring System

Mohamed Attia Waly
Faculty of Science (Damiatta), Chemistry Department Mansoura University, Egypt

Pyrazino[1,3]diazepine represents a new ring system and was synthesized via annulation of the diazepine ring onto the preformed pyrazine derivatives. These compounds were synthesized as potential non-peptide, small-molecule IL-8 receptor antagonists. Different new pyrazine derivatives were also prepared for the syntheses of these new ring systems.

Keywords: Guanidine nitrate; S-methylisothiourea sulphate; pyrazine; dimethylacetylene dicarboxylate; non-peptide small-molecule IL-8 receptor antagonists.