Complexation of Iron with Piroxicam – Evaluation via Response Surface Methodology
Mohammad Edrissia and Nima Razzaghi aslb,*
a Department of Chemical engineering, Amirkabir University of Technology, Tehran, Iran.
b Department of organic colorants & environmental studies, Institute for colorants, paints and coatings, Tehran, Iran.
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A response surface methodology (RSM) based on a Box-Behnken design was applied for study on ferrous ions binding ability to piroxicam in aqueous solution as a function of three numerical factors (extraction time, pH, piroxicam concentration) and extractant type as a categorical variable each in three levels. Analysis of variance (ANOVA) provided a supporting evidence for quadratic model to fit the experimental data with a correlation value squared (r2) of 0.9433. All the experimental data resulted by a selective extraction-spectrophotometric method. The relative standard deviation (RSD) was found to be 0.63%.
Keywords: Piroxicam, iron, spectrophotometry, box-behnken design.