Synthesis, Characterization and Antimicrobial Activity of Long-Chain Hydrazones

Abdul Rauf,a* Mudasir R. Bandaya and Rayees H. Mattoob

aSection of Oils and Fats, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
bDepartment of Biochemistry, Aligarh Muslim University, Aligarh 202002, India
* Corresponding author: E-mail: abduloafchem@gmail.com
Mob.: 0091-9412545345

Abstract
Fatty acids containing hetero atoms are regarded as potential antimicrobial agents. Thus eight different hydrazones 2ad and 3ad were synthesized from four fatty acid hydrazides namely undecanoic hydrazide (1a), octadecanoic hydrazide (1b), 12-hydroxyoctadecanoic hydrazide (1c) and 9-hydroxyoctadecanoic hydrazide (1d) by condensing them with carbonyl group of methyl acetoacetate and acetylacetone. The structural elucidation of these compounds is based on their spectral data (IR, 1H NMR, 13C NMR and MS). These compounds were also screened for their microbial activity against Escherichia coli, Staphylococcus aureus and Staphylococcus albus by cup-plate method at 100 g/ml of DMF using chloromycetin as a standard drug.

Keywords: Fatty acid hydrazones, antimicrobial activity, IR, 1H NMR, 13C NMR, MS.