An Efficient Procedure for the Synthesis of Hantzsch 1,4-Dihydropyridines Under Mild Conditions

Arash Ghorbani-Choghamarani,*,a Mohammad Ali Zolfigol,*,b Peyman Salehi,c Ezat Ghaemi,b Elaheh Madrakian,b Hossein Nasr-Isfahanid and Mozhjgan Shahamirianb

a Department of Chemistry, Faculty of Science, Ilam University, P.O. Box, 69315516, Ilam, Iran
b Faculty of Chemistry, Bu-Ali Sina University, P.O. Box 6517838683, Hamadan, Iran
c Department of Phytochemistry, Aromatic and Medicinal Plants and Drug Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran
d College of Chemistry, Shahrood University of Technology, Shahrood, Iran
* Corresponding author: E-mail: arashghch58@yahoo.com  (A. Ghorbani-Choghamarani)
zolfi@basu.ac.ir. (M. A. Zolfigol)

Abstract
A simple and efficient one-pot synthesis of 1,4-dihydropyridine derivatives was achieved via condensation of methyl acetoacetate or ethyl propiolate with various alkyl and aryl aldehydes and ammonium acetate at 80 C under solvent free conditions with good to excellent yields.

Keywords: 1,4-Dihydropyridines, ethyl propiolate, methyl acetoacetate, ammonium acetate, solvent-free conditions