New Benzo- and Thieno-fused Spirolactams

Peter Stanetty,* Beatrix Sigl, Michael Schnürch and Marko D. Mihovilovic

Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria

* Corresponding author: E-mail:

A short and efficient approach leading to new spiro compounds joining benzo- and thieno-fused lactams and piperidine is presented. Various derivatives were prepared by alkylation of 1-methylpiperidinecarboxylates, cyclization to spiroketones, and subsequent Beckmann rearrangement of the corresponding oximes.

Keywords: Spiro compounds, Beckmann rearrangement, oximes, lithiation, ring extension