Synthesis and Biological Evaluation of Novel Chalcone-Porphyrin Conjugates

Vanda Vaz Serra,1 Fátima Camões,2 Sandra I. Vieira,2 Maria A. F. Faustino,1 João P. C. Tomé,1 Diana C. G. A. Pinto,1 Maria G. P. M. S. Neves,1 Augusto C. Tomé,1 Artur M. S. Silva,1 Edgar F. da Cruz e Silva2* and José A. S. Cavaleiro1,*

1 Department of Chemistry, QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal
2 Centre for Cell Biology, University of Aveiro, 3810-193 Aveiro, Portugal

* Corresponding author: E-mail:;

Studies on the synthesis, structural characterization and biological evaluation of novel chalcone-porphyrin derivatives are described. The photodynamic effect, intracellular localization and cellular uptake of the new conjugates were evaluated in vitro in COS-7 cells. All derivatives exhibited high stability and yielded good fluorescence under light irradiation. None of the chalcone-porphyrins proved to be cytotoxic and/or phototoxic for COS-7 cells.

Keywords: porphyrins, chalcones, medicinal applications, fluorophores, fluorine