THE SYNTHESES OF 1-(2-NAPHTHYL)PIPERAZINE DERIVATIVES. NOVEL SPIPERONE-CONTAINING PROBES

Andrej Petriè*
Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia

Jorge R. Barrio
Department of Molecular and Medical Pharmacology and the Laboratory of Structural Biology and Molecular Medicine, UCLA, School of Medicine, Los Angeles, California 90095, USA

Abstract

The synthesis of 1-(6-piperazino-2-naphthyl)-1-ethanone, a reactive fluorescent dye, is described. To this dye spiperone, a highly potent dopaminergic D2 receptor ligand, was conjugated giving a new fluorescent probe. By the Knoevenagel reaction with malononitrile and subsequent deprotection, Vis range fluorescent probe was formed.