Abdel-Sattar S. Hamad* and Ahmed I. Hashem
Department of Chemistry, Faculty of Science, University of Ain Shams, Abbassia 11566, Cairo, Egypt. Tel./ Fax; (00) 202-4831836  e-mail; hamad@asunet.shams.eun.eg
 

Abstract
Novel of 6-aryl-4-[(2-furyl)methylidene]-1-(tosylaminocarbonyl)-1,2,3,4-tetrahydropyridazine-3-ones 4a-d were prepared by the reaction of a-aracyl-b-(2-furyl)acrylic acid hydrazides 2a-d with tosylisocyanate. This has been shown to occur by initial formation of N1-[2-aroylmethyl-3-(2-furyl)acroyloyl]-N2-(tosylaminocarbonyl)hydrazines 3a-d followed by acid catalyzed cyclization to afford 5-[1-aroylmethyl-2-(2-furyl)-1-ethenyl]-2-(tosylamino)-1,3,4-oxadiazoles 5a-d.