Biljana Nigović,* Nikola Kujundžić, Krešimir Sanković

Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia

 
Dražen Vikić-Topić

Ruđer Bošković Institute, NMR Center, P.O. Box 180, 10002 Zagreb, Croatia
 
 
 

ABSTRACT

Complexes of cobalt(II), nickel(II) and copper(II) with 2-pyrrolidone-5-hydroxamic acid (HL) have been investigated by the combined pH-spectral titration method at 25?0.1 ?C in aqueous medium of 0.2 M ionic strength. Cobalt(II) and nickel(II) form ?ML?+, ?ML2? and ?ML2H-1?? complexes with HL, while in the case of copper(II) mononuclear ?CuL?+ and dinuclear ?Cu2L2H-2? species are present. The formation constants obtained and the possible binding modes for the complexes in aqueous solution are discussed. 1H NMR, IR and EPR measurements have furnished additional information on the nature of binding in the complexes formed.