SYNTHESIS AND REACTIVITY OF MANNICH BASES. XIV. BASE-CATALYZED CYCLOCONDENSATION OF ?–AMINOKETONES TO 1,5-BENZODIAZEPINES AND 1,4-NAPHTHODIAZEPINES
 
 

Gheorghe Roman
Department of Chemistry, “Transilvania” University, 29 Eroilor Blvd., Brașov, RO-2200, Romania
 
Eugenia Comaniță
Department of Organic Chemistry, “Gh. Asachi” Technical University, 71A D. Mangeron Blvd.,
Iași,RO-6600, Romania

Bogdan Comaniță
National Research Council, Institute for Chemical Process and Environmental Technology,
Montreal Road Campus, K1A 0R6, Ottawa, Canada
 
 

ABSTRACT

Several 2,3-dihydro-1,5-benzodiazepines and 2,3-dihydronaphtho[2,3-b]-1,4-diazepines were  prepared via cyclocondensation of the corresponding ortho-arylenediamine with 3-dialkylaminopropiophenone hydrochlorides in ethanol in the presence of anhydrous sodium acetate.