Synthesis of Some Biologically Active Pyrazoles and C-Nucleosides

Aymn El-Sayed Rashad,^a,* Ahmed Hussien Shamroukh,^a Mohamed Ibrahim Hegab,^a and Hassan Mohamed Awad^b
a Photochemistry Department,
^b Department of Natural and Microbial Products, National Research Centre, Dokki, Cairo, Egypt. E-mail: aymnelzeny@yahoo.com

Abstract
(5,6-Dihydronaphtho[1′,2′:4,5]thieno[2,3-d]pyrimidin-11-yl)-hydrazine (1) was used as a precursor for preparation of some novel 1-(5,6-dihydronaphtho[1′,2′:4,5]thieno[2,3-d]pyrimidin-11-yl)-pyrazole derivatives 2-7. Also, some acyclic and cyclic C-nucleosides 8 and 10-12 were prepared by treating compound 1 with aldoses. Some of the prepared products showed potent antimicrobial activity.

Key words: Thieno[2,3-d]pyrimidine, pyrazole, aldoses, C-nucleosides