Synthesis of Some Biologically Active Pyrazoles and C-Nucleosides

Aymn El-Sayed Rashad,a,* Ahmed Hussien Shamroukh,a Mohamed Ibrahim Hegab,a and Hassan Mohamed Awadb
a Photochemistry Department,
b Department of Natural and Microbial Products, National Research Centre, Dokki, Cairo, Egypt. E-mail:

(5,6-Dihydronaphtho[1′,2′:4,5]thieno[2,3-d]pyrimidin-11-yl)-hydrazine (1) was used as a precursor for preparation of some novel 1-(5,6-dihydronaphtho[1′,2′:4,5]thieno[2,3-d]pyrimidin-11-yl)-pyrazole derivatives 2-7. Also, some acyclic and cyclic C-nucleosides 8 and 10-12 were prepared by treating compound 1 with aldoses. Some of the prepared products showed potent antimicrobial activity.

Key words: Thieno[2,3-d]pyrimidine, pyrazole, aldoses, C-nucleosides