A Facile Synthesis of Ethyl (3-Oxo-5b-Cholan)-24-YL Oxalate

Lutfun Nahara,*, Satyajit D. Sarkerb and Alan B. Turnera

aJapp Laboratory, Department of Chemistry, University of Aberdeen, Aberdeen AB24  3UE, Scotland, UK
bSchool of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK

A facile synthesis of ethyl (3-oxo-5b-cholan)-24-yl oxalate (8) has been achieved from lithocholic acid (1) in 5 steps with a 64% yield.  Comprehensive NMR spectroscopic data interpretations for all new compounds are presented.

Keywords: lithocholic acid, methyl lithocholate, oxalyl chloride, esterification, NMR