Ali Pourjavadi,* Hamid Salimi, Shahram Barzegar, Bagher Eftekhari-Sis
Laboratory, Department of Chemistry, Sharif University of Technology, P.O. Box
11365-9516, Tehran, Iran.
Poly(2-acrylamido-2-methyl propane sulphonic acid) crosslinked with N,Ní-methylene bisacrylamide catalyses efficiently the three component condensation reaction of an aromatic aldehyde, β-ketoester and urea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yield.
Keywords: Biginelli reaction, three-component reaction, polymeric catalyst