The Reaction of 2-Aminocyclohexeno[b]thiopheneDerivatives with Ethoxycarbonyl isothiocyanate: Synthesis of Fused Thiophene Derivatives withAntibacterial and Antifungal Activities

Wagnat W. Wardakhana*, Nadia A. Loucab and Mona M. Kamelc

^a National organization for Drug Control & Research, P.O. 29, Cairo, A. R. Egypt,
^b Hormones Department, National Research Center, Dokki, Giza, A. R. Egypt
^c Department of organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, A. R. Egypt.
E-mail: wagnatward@hotmail.com

Abstract
The reaction of 2-amino-tetrahydrobenzo[b]thiophene derivatives 1a–d with ethoxycarbonyl isothiocyanate (2) gave the
tetrahydrobenzo[b]thiophen-2-thiourea derivatives 3a–d. The latter products underwent ready cyclizations when heated
in sodium ethoxide solution to give annulated derivatives 4a–d. Compounds 3a–d also underwent hetero-cyclizations to
give fused thiophene derivatives with antibacterial and antifungal activities.

Keywords: Thiophene, pyrazole, pyrimidine, fused derivatives