Complexation of Iron with Piroxicam – Evaluation via Response Surface Methodology

Mohammad Edrissi^a and Nima Razzaghi asl^b,*
^a Department of Chemical engineering, Amirkabir University of Technology, Tehran, Iran.
^b Department of organic colorants & environmental studies, Institute for colorants, paints and coatings, Tehran, Iran.
Tel: +98-09122763023, Fax: +98(021)22947537
E-mail: nrazzaghi@gmail.com

Abstract
A response surface methodology (RSM) based on a Box-Behnken design was applied for study on ferrous ions binding ability to piroxicam in aqueous solution as a function of three numerical factors (extraction time, pH, piroxicam concentration) and extractant type as a categorical variable each in three levels. Analysis of variance (ANOVA) provided a supporting evidence for quadratic model to fit the experimental data with a correlation value squared (r²) of 0.9433. All the experimental data resulted by a selective extraction-spectrophotometric method. The relative standard deviation (RSD) was found to be 0.63%.

Keywords: Piroxicam, iron, spectrophotometry, box-behnken design.