Preparation and Characterization of a Diclofenac Sensitive Electrode Based on a PVC Matrix Membrane

Zholt Kormosh,^1* Iryna Hunka² and Yaroslav Bazel³

¹ Department of Analytical Chemistry, Volyn National University, Voli av., 13, 43021, Lutsk, Ukraine,
² Department of Analytical Chemistry, Volyn National University, Voli av., 13, 43021, Lutsk, Ukraine
³ Department of Analytical Chemistry, Uzhgorod National University, Pidgirna str., 46, 88000 Uzhgorod, Ukraine
³ Department of Analytical Chemistry, P. J. Safarik University, Moyzesova str., 11, 04154 Kosice, Slovakia
* Corresponding author: E-mail: kormosh@univer.lutsk.ua

Abstract
A new diclofenac-selective electrode based on an ion associate of diclofenac with a basic dye BIK as a membrane carrier was developed. The electrode exhibits a good Nernstian slope of 60.0 ± 1.1 mV decade^-1 and a linear range of 1.0 · 10^–4 to 5.0 · 10^–2 mol L^–1 for diclofenac. The detection limit was 5.0 · 10^–5 mol L^–1. The electrode has a fast response time 2–3 s and can be used for more the four months. The selective coefficients were determined and this electrode can be used in the pH range of 7–11. The analytical results obtained by applying the proposed method compared very favorably with who’s obtained by the Ukrainian Pharmacopoeia Standard procedure. This membrane electrode was successfully tested in for the determination of diclofenac in pharmaceuticals.

Keywords: Diclofenac; Ion-selective electrode; Potentiometry; Pharmaceutical analysis.