A Novel Catalyst for One-Pot Synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones via Biginelli Reaction Under Solvent-Free Conditions

Taoues Boumoud,^a Boudjemaa Boumoud,^a Salah Rhouati,^a Ali Belfaitah,^a Abdelmadjid Debachea,* and Paul Mosset^b

^a Laboratoire des produits naturels d’origine végétale et de synthèse organique,
Département de Chimie, Faculté des Sciences, Université Mentouri de Constantine, 25000 Constantine, Algeria.
Phone / Fax: +213 31614622
^b Sciences Chimiques de Rennes, CNRS UMR 6226, ENSCR, Avenue du Général Leclerc, 35700 Rennes, France.
* Corresponding author: E-mail: b_boumoud@yahoo.fr

Abstract
An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a onepot three-component cyclocondensation reaction of an aldehyde, β-keto-ester, and urea/thiourea under solvent-free conditions using magnesium(II) nitrate hexahydrate as a catalyst.

Keywords: Biginelli reaction, multicomponent reaction, dihydropyrimidin-2-(1H)-ones, Mg(II) nitrate hexahydrate, solvent-free conditions.