An Efficient Procedure for the Synthesis of Hantzsch 1,4-Dihydropyridines Under Mild Conditions

Arash Ghorbani-Choghamarani,*^,a Mohammad Ali Zolfigol,*^,b Peyman Salehi,^c Ezat Ghaemi,^b Elaheh Madrakian,^b Hossein Nasr-Isfahani^d and Mozhjgan Shahamirian^b

^a Department of Chemistry, Faculty of Science, Ilam University, P.O. Box, 69315516, Ilam, Iran
^b Faculty of Chemistry, Bu-Ali Sina University, P.O. Box 6517838683, Hamadan, Iran
^c Department of Phytochemistry, Aromatic and Medicinal Plants and Drug Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran
^d College of Chemistry, Shahrood University of Technology, Shahrood, Iran
* Corresponding author: E-mail: arashghch58@yahoo.com  (A. Ghorbani-Choghamarani)
zolfi@basu.ac.ir. (M. A. Zolfigol)

Abstract
A simple and efficient one-pot synthesis of 1,4-dihydropyridine derivatives was achieved via condensation of methyl acetoacetate or ethyl propiolate with various alkyl and aryl aldehydes and ammonium acetate at 80 °C under solvent free conditions with good to excellent yields.

Keywords: 1,4-Dihydropyridines, ethyl propiolate, methyl acetoacetate, ammonium acetate, solvent-free conditions