An Efficient, One-pot Synthesis of Novel 3,5-Disubstituted-1,2,4-Oxadiazoles from Long-Chain Carboxylic Acid Derivatives

Shweta Sharma, Saloni Gangal and Abdul Rauf*

Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
* Corresponding author: E-mail:

A series of novel 3,5-disubstituted-1,2,4-oxadiazoles have been synthesized utilizing either long-chain alkenoates or acyl chlorides with amidoximes in presence of base. The structures of the synthesized compounds were elucidated by IR, mass, 1H and 13C NMR spectroscopy and elemental analysis.

Keywords: 3,5-Disubstituted-1,2,4-oxadiazoles, amidoximes, long-chain alkenoates