Crystal Structure and Thermodynamic Properties of N, N-dimethylnorephedrine Hydrochloride (C11H18NOCl) (s)

You-Ying Di,a,* Yu-Xia Kong,a Wei-Wei Yang,a Da-Qi Wanga and Zhi-Cheng Tanb

a College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, Shandong Province, P. R. China
b Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
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Crystal structure of N, N-dimethylnorephedrine hydrochloride (C11H18NOCl) (s) has been determined by an X-ray crystallography. The compound is orthorhombic P212121. Unit cell parameters are a = 7.2486(19) Å, b = 9.674(3) Å, c = 16.952(5) Å; α= 90°, β= 90°, γ= 90°, and Z = 4. Low-temperature heat capacities of the compound were measured by a precision automated adiabatic calorimeter over the temperature range from 80 to 390 K. A polynomial equation of heat capacities as a function of the temperature in the region of 80–390 K was fitted by least square method. Based on the fitted polynomial equation, the smoothed heat capacities and thermodynamic functions of the compound relative to the standard reference temperature 298.15 K were calculated with 5 K step. In addition, DSC technique was used to determine the melting process of the compound.

Keywords: N, N-dimethylnorephedrine hydrochloride; X-ray crystallography; adiabatic calorimetry; low-temperature heat capacity; thermodynamic function