Peter Stanetty,^* Beatrix Sig^l, Michael Schnürch and Marko D. Mihovilovic

Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria

* Corresponding author: E-mail: peter.stanetty@tuwien.ac.at

Abstract
A short and efficient approach leading to new spiro compounds joining benzo- and thieno-fused lactams and piperidine is presented. Various derivatives were prepared by alkylation of 1-methylpiperidinecarboxylates, cyclization to spiroketones, and subsequent Beckmann rearrangement of the corresponding oximes.

Keywords: Spiro compounds, Beckmann rearrangement, oximes, lithiation, ring extension