Synthesis and Identification of Some Impurities of Irbesartan

Stanislav Rádl,* Jan Stach, Jaroslav Havlíček, Marcela Tkadlecová, and Lukáš Plaček

Zentiva, U kabelovny 130, 102 01 Prague 10, Czech Republic

* Corresponding author: E-mail: stanislav.radl@zentiva.cz

Abstract
Synthesis of two principal impurities of irbesartan prepared via its N-trityl derivative is described. The impurities were isolated and unambiguouesly identified by NMR techniques. Spectral characteristics (IR, UV, MS) of these compounds are also given.

Keywords: Irbesartan, Impurities, Identification, NMR, LC MS, IR, UV.