A Convenient Synthesis of 4-Benzyl-2-(2-(4-oxo-2-thioxothiazolidin-5-ylidene)ethyl)-2H-1,4-benzoxazin-3(4H)-ones and 5-(2-(4-Benzyl-3-oxo-3,4-dihydro-2H- 1,4-benzoxazin-2-yl)ethylidene)thiazolidine-2,4-diones

Nace Zidar, Jure Kladnik and Danijel Kikelj*

Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000 Ljubljana, Slovenia

* Corresponding author: E-mail: danijel.kikelj@ffa.uni-lj.si

Abstract
4-Benzyl-2-(2-(4-oxo-2-thioxothiazolidin-5-ylidene)ethyl)-2H-1,4-benzoxazin-3(4H)-ones and 5-(2-(4-benzyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)ethylidene)thiazolidine-2,4-diones are conveniently prepared from 2-aminophenol and rhodanine or thiazolidine-2,4-dione derivatives using microwave-assisted synthesis.

Keywords: 2H-1,4-benzoxazin-3(4H)-one, rhodanine, 5-ylidene-2-thioxothiazolidin-4-one, microwave-assisted synthesis