The Direct Formation of 2-Cyano-4-amidopyridine via α-Cyanation of 4-Amidopyridine N-Oxide with Dimethylcarbamoyl Chloride and Cheap Potassium Cyanide

Zhibao Huo,¹ Teruo Kosugi² and Yoshinori Yamamoto^1,*

¹ Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
² Fukuzyu Pharmaceuticals Co., Ltd, Toyama 939-8261, Japan

* Corresponding author: E-mail: yoshi@mail.tains.tohoku.ac.jp

Abstract
Reaction of 4-amidopyridine N-oxide with dimethylcarbamoyl chloride and potassium cyanide in CH₃CN at 120 °C gave the corresponding 2-cyano-4-amidopyridine in a good yield.

Keywords: Potassium cyanide, α-cyanation, pyridine N-oxide, 2-cyano-4-amido pyridine, 4-amidopyridine N-oxide.