Biologically Active Tetraazamacrocyclic Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

Dharam P. Singh,1,* Ramesh Kumar,1 Monika Kamboj1 and Kiran Jain2

1 Department of Chemistry, National Institute of Technology, Kurukshetra-136119, India.
2 Department of Chemistry, M.L.N. College, Yamunanagar-135001, Haryana, India.
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A new series of the macrocyclic complexes of type [M(C16H28N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and X = Cl–1, NO3–1, CH3COO–1 has been synthesized by [2+2]condensation reaction of ethylenediamine with and acetonylacetone (diacetonyl) in the presence of divalent metal ions. The complexes have been characterized with the help of elemental analyses, conductance measurements, electronic, NMR and infrared spectral studies. On the basis of these studies, a six coordinate distorted octahedral geometry has been proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity. Some of the complexes showed remarkable antibacterial activity against some selected bacterial strains.

Keywords: Antibacterial activity; minimum inhibitory concentration; macrocyclic complexes; infrared spectra.