Mohamed Abdel-Megid,1,* Mohamed Awas,1 Magdy Seada,1 Kamelia Elmahdy1 and Mortta El-Sayed2
1 Chemistry Department, Faculty of Education, Ain Shams University, Roxy, Cairo,
Egypt
2 Environmental Research Laboratory, Theodor Bilharz Research Institute
* Corresponding author: E-mail: mabdelmegid@yahoo.com
Abstract
2-Carbethoxymethylthiopyrimidinone derivative 1b was utilized for the synthesis
of some new diheterocyclic thioethers
via its reaction with some acetals followed by cyclization of the products with
2-aminoheterocyclic compounds or
through the reaction of 1b with p-tolyldiazonium chloride followed by the
reaction of the product with active methylene
compounds. Also, some new thiazolopyrimidines were synthesized from
2-mercaptopyrimidine 1a or from 5-pyrimidinylmercaptoacetic
acid derivative 1c. The molluscicidal activity of some synthesized compounds
towards Biomphalaria
alexandrina snails, the intermediate host of Schistosoma mansoni, was
investigated.
Keywords: Diheterocyclic thioethers, thiazolopyrimidines, molluscicidal activity.