New Mono, Bis-2,2-(arylidineaminophenyl)benzimidazoles: Synthesis and Antimicrobial Investigation

Rondla Rohini,1 P. Muralidhar Reddy,1,2 Kanne Shanker1 and Vadde Ravinder1,*

1 Department of Chemistry, Kakatiya University, Warangal-506 009, A. P., India
2 Department of Chemistry, National DongHwa University, Hualien, Taiwan
* Corresponding author: E-mail:

Some new mono and bis-2,2-(arylidineaminophenyl)benzimidazole derivatives have been synthesized and characterized via IR, 1H NMR, 13C NMR, MS and elemental analysis. All the products were screened for antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Salmonella typhimurium, Escherichia coli and Klebsiella pneumonia and antifungal activity against Aspergillus niger, Candida albicans and Trichoderma viridae. Compounds 5, 6 exhibited potent in vitro antibacterial activity against S. aureus, B. subtilis, S. pyogenes whereas compounds 13–16 exerted superior activity against all tested bacterial and fungal strains even than standard drugs Ampicillin and Ketoconazole.

Keywords: 2,2-(arylidineaminophenyl)benzimidazole, synthesis, antibacterial activity, antifungal activity